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Participants receiving the highest dose (12 mg weekly) achieved a mean body weight reduction of approximately 24% over 48 weeks results that exceeded those seen with currently approved agents at the time of publication

Table 2: Adverse Reactions Occurring in 20% of Patients in KEYNOTE-189 Table 3 summarizes the laboratory abnormalities that worsened from baseline in at least 20% of patients treated with pemetrexed for injection, pembrolizumab, and platinum

This retrograde signaling from mitochondria to nucleus increases expression of cytoprotective enzymes, helping cells cope with oxidative stress

cDNA was prepared using ReverTra Ace (Toyobo) according to the manufacturers instructions